Though many New York City buildings play host to artists, musicians, and makers of all stripes, the creative hub of Manhattan might just be 195 Chrystie Street on the city’s Lower East Side. You’d never know it from looking at the well-worn exterior of the nine-story structure, but the tenants within—architects, rising fashion stars, sculptors, and even pickle makers—produce a rather mind-blowing artistic output on a daily basis.

In its lifetime, the building—originally built in the early 20th century—has played host to garment factories and internet start-ups. In 1974, when the neighborhood was considered seedy, the Talking Heads formed on the top floor. Band members reportedly lived illegally in a loft space and soon played their first show blocks away—opening for the Ramones at CBGB. To this day, David Byrne’s world-music record label Luaka Bop is in the building.

Whether the occupants know the history or are simply drawn to the building’s high ceilings, the funky neighborhood, or the proximity to the contemporary art-focused New Museum (which rises just feet from the west-facing studios), all of them contribute to its unique character. Innovative use of limited square footage and personality-filled walls, floors, and windows are commonplace. In New York, creative types might be pretty used to working in tight quarters; you are about to meet six who have made their small spaces at 195 Chrystie stand out as brightly as their creative works. Let them show you how they did it with projects and tips you can try at home. Get ready to make the most of the space you have.

Check out the spaces by clicking the name below.

Carter and Cunningham

Make Workshop

Rick's Picks

Rich Brilliant Willing

Erica Weiner Jewelry

Tim Hamilton